– Oral Plasma Kallikrein Inhibitor Blocks VEGF-induced Retinal
Vascular Hyperpermeability –
CAMBRIDGE, Mass.--(BUSINESS WIRE)--May 2, 2018--
KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage
pharmaceutical company focused on the discovery, development, and
commercialization of small molecule protease inhibitors, today announced
data in support of the Company’s development activities in diabetic
macular edema (DME) from an oral presentation at The Association for
Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting in
“Our findings are consistent with our belief that oral plasma kallikrein
inhibitors may provide an opportunity to reduce the edematous effects of
VEGF in diabetic macular edema patients,” said Andrew Crockett, Chief
Executive Officer of KalVista. “We continue to evaluate potential oral
compounds for treatment of diabetic macular edema in our preclinical
research while our intravitreal compound for DME, KVD001, enrolls a
Phase 2 clinical trial.”
The study investigated the effects of an orally administered plasma
kallikrein inhibitor KV123833 on VEGF-induced retinal edema in mice.
KV123833 is a novel, potent, and highly selective plasma kallikrein
inhibitor with a 3nM Ki for plasma kallikrein and selectivity of
1000-fold over related serine proteases. In the study, KV123833 was
administered both subcutaneously and orally, to evaluate the comparative
efficacy of both routes of administration. Efficacious plasma exposure
of drug for both subcutaneous administration and oral dosing experiments
was confirmed using an ex vivo plasma kallikrein activity. Retinal
exposure following systemic administration of KV123833 was about 0.6
ng/mg retinal tissue and intravitreal injection of VEGF increased drug
concentrations in the retina by 2-fold (p=0.038). VEGF-induced retinal
vascular permeability in mice was decreased by 85% (p=0.0076) and 86%
(p=0.028) in mice receiving subcutaneous administration and orally
administered KV123833, respectively. These data demonstrate that orally
administered KV123833 is highly effective in reducing VEGF-induced
retinal edema in mice, and displays similar efficacy to subcutaneous
About KalVista Pharmaceuticals, Inc.
Pharmaceuticals, Inc. is a pharmaceutical company focused on the
discovery, development, and commercialization of small molecule protease
inhibitors for diseases with significant unmet need. The initial focus
is on inhibitors of plasma kallikrein, which is an important component
of the body’s inflammatory response and which, in excess, can lead to
increased vascular permeability, edema and inflammation. KalVista has
developed a proprietary portfolio of novel, small molecule plasma
kallikrein inhibitors initially targeting hereditary angioedema (HAE)
and diabetic macular edema (DME). The Company has created a structurally
diverse portfolio of oral plasma kallikrein inhibitors and is advancing
multiple drug candidates into Phase 1 clinical trials for HAE.
KalVista’s most advanced program, an intravitreally administered plasma
kallikrein inhibitor known as KVD001, has successfully completed its
first-in-human study in patients with DME and began a Phase 2 clinical
trial in 2017.
For more information, please visit www.kalvista.com.
This press release contains
"forward-looking" statements within the meaning of the safe harbor
provisions of the U.S. Private Securities Litigation Reform Act of 1995.
Forward-looking statements can be identified by words such as:
"anticipate," "intend," "plan," "goal," "seek," "believe," "project,"
"estimate," "expect," "strategy," "future," "likely," "may," "should,"
"will" and similar references to future periods. These statements are
subject to numerous risks and uncertainties that could cause actual
results to differ materially from what we expect. Examples of
forward-looking statements include, among others, available funding, our
cash runway and future clinical trial timing and results. Further
information on potential risk factors that could affect our business and
its financial results are detailed in the annual report on Form 10-K
filed on July 27, 2017, our most recent Quarterly Report on Form 10-Q,
and other reports as filed from time to time with the Securities and
Exchange Commission. We undertake no obligation to publicly update any
forward-looking statement, whether written or oral, that may be made
from time to time, whether as a result of new information, future
developments or otherwise.
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Source: KalVista Pharmaceuticals, Inc.
KalVista Pharmaceuticals, Inc.
Leah Monteiro, 857-999-0808
Corporate Communications & Investor Relations