75000 - Document - Document and Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Disclosure - Income Taxes - Schedule of Reconciliation between Effective Tax Rates and Statutory Rates (Detail) 2
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75030 - Disclosure - Leases - Summary of Maturity of Undiscounted Payments Due Under Lease Liabilities and Present Value of Liabilities (Detail) 2
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75040 - Statement - Consolidated Balance Sheets (Parenthetical)
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75050 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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75060 - Statement - Consolidated Statements of Changes in Stockholders' Equity
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75070 - Statement - Consolidated Statements of Changes in Stockholders' Equity (Parenthetical)
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75080 - Statement - Consolidated Statements of Cash Flows
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995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995465 - Disclosure - Description of Business and Basis of Presentation
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995475 - Disclosure - Summary of Significant Accounting Policies
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995485 - Disclosure - Fair Value Measurements
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995495 - Disclosure - Prepaid Expenses and Other Current Assets
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995505 - Disclosure - Property and Equipment
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995515 - Disclosure - Accrued Expenses
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995525 - Disclosure - Stockholder's Equity
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995535 - Disclosure - Stock-Based Compensation
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995545 - Disclosure - Commitments and Contingencies
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995555 - Disclosure - Leases
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995565 - Disclosure - Purchase and Sale Agreement
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995575 - Disclosure - License, Supply and Distribution Agreement
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995585 - Disclosure - Income Taxes
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995595 - Disclosure - Defined Contribution Plans
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995605 - Disclosure - Segment Information
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995615 - Disclosure - Other Income (Expenses), Net
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995625 - Disclosure - Subsequent Events
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995635 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995645 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995655 - Disclosure - Fair Value Measurements (Tables)
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995665 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)
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995675 - Disclosure - Property and Equipment (Tables)
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995685 - Disclosure - Accrued Expenses (Tables)
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995695 - Disclosure - Leases (Tables)
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995705 - Disclosure - Income Taxes (Tables)
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995715 - Disclosure - Stock-Based Compensation (Tables)
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995725 - Disclosure - Segment Information (Tables)
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995735 - Disclosure - Other Income (Expenses), Net (Tables)
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995745 - Disclosure - Description of Business and Basis of Presentation - Additional Information (Detail)
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995755 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail)
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995765 - Disclosure - Summary of Significant Accounting Policies - Schedule of Cash and Cash Equivalents and Restricted Cash (Detail)
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995775 - Disclosure - Summary of Significant Accounting Policies - Estimated Useful Life of Property and Equipment (Detail)
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995785 - Disclosure - Summary of Significant Accounting Policies - Schedule of Potential Dilutive Common Share Equivalents (Detail)
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995795 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liability Measured at Fair Value (Detail)
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995805 - Disclosure - Fair Value Measurements - Additional Information (Detail)
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995815 - Disclosure - Fair Value Measurements - Summary of Fair Values of Company's Marketable Securities By Type (Detail)
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995825 - Disclosure - Fair Value Measurements - Summary of Scheduled Maturity for Marketable Securities (Detail)
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995835 - Disclosure - Property and Equipment - Components of Property and Equipment (Detail)
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995845 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Details)
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995855 - Disclosure - Property and Equipment - Additional Information (Detail)
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995865 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Detail)
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995875 - Disclosure - Stockholder's Equity - Additional Information (Detail)
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995885 - Disclosure - Stock-Based Compensation - Additional Information (Detail)
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995895 - Disclosure - Stock-Based Compensation - Schedule of Fair Value of Share-based Awards Measured with Weighted-Average Assumptions (Detail)
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995905 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Detail)
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995915 - Disclosure - Stock-Based Compensation - Summary of Option Activity (Detail)
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995925 - Disclosure - Stock-Based Compensation - Summary of Activity In Connection With RSU and PSU (Detail)
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995935 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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995945 - Disclosure - Leases - Additional Information (Detail)
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995955 - Disclosure - Leases - Summary of Lease Costs (Detail)
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995965 - Disclosure - Leases - Summary of Maturity of Undiscounted Payments Due Under Lease Liabilities and Present Value of Liabilities (Detail)
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995975 - Disclosure - Leases - Summary of Lease Term and Discount Rate (Detail)
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995985 - Disclosure - Leases - Summary of Cash Paid for Amounts Included in Measurement of Lease Liabilities (Detail)
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995995 - Disclosure - Purchase and Sale Agreement - Additional Information - (Detail)
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996005 - Disclosure - License, Supply and Distribution Agreement - Additional Information (Details)
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996015 - Disclosure - Income Taxes - Schedule of Components of the Company's Loss Before Income Taxes (Detail)
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996025 - Disclosure - Income Taxes - Additional Information (Detail)
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996035 - Disclosure - Income Taxes - Schedule of Reconciliation between Effective Tax Rates and Statutory Rates (Detail)
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996045 - Disclosure - Income Taxes - Schedule of Tax Effect of Significant Temporary Differences Representing Deferred Tax Assets and Liabilities (Detail)
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996055 - Disclosure - Defined Contribution Plans - Additional Information (Detail)
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996065 - Disclosure - Segment Information - Additional Information (Details)
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996075 - Disclosure - Segment Information - Summary of Selected Financial Information with Respect to Single Operating Segment (Details)
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996085 - Disclosure - Other Income (Expenses), Net - Summary of Other Income and Expenses (Detail)
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996095 - Disclosure - Other Income (Expenses), Net - Additional Information (Detail)
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996105 - Disclosure - Subsequent Events - Additional Information (Detail)
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Proceeds from Sale and Maturity of Debt Securities, Available-for-sale, Total
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Sales and maturities of available for sale securities
Other Nonoperating Income (Expense) [Member]
Other Income [Member]
Statement [Line Items]
Statement [Line Items]
Summary of lease term and discount rate.
Summary of Lease Term and Discount Rate [Table Text Block]
Summary of Lease Term and Discount Rate
Cybersecurity Risk Board of Directors Oversight [Text Block]
Plan Name [Domain]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash, Cash Equivalents and Investments [Table Text Block]
Schedule of Financial Assets and Liability Measured at Fair Value
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Letter Of Credit
Letter of credit.
Letter of credit
Office Equipment [Member]
Fair Value, Recurring and Nonrecurring [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Deferred tax assets operating lease liabilities.
Deferred tax assets operating lease liabilities
Operating lease liabilities
Number of operating segments
Number of Operating Segments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable
Stock Issued During Period, Value, Restricted Stock Award, Gross
Release of restricted stock units
Fair Value Hierarchy and NAV [Axis]
Auditor Name
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share based compensation arrangement by share based payment award number of shares reserved for grant.
Share based compensation arrangement by share based payment award number of shares reserved for grant
Shares reserved for grants
Number of warrants or rights exercised
Class of Warrants or Rights Exercised
Class of warrants or rights exercised.
Issuance of common stock from equity incentive plans, shares
Stock Issued During Period, Shares, Employee Benefit Plan
Tax Credit Carryforward, Name [Domain]
Interest Expense Related To The Sale Of Future Royalties
Interest expense related to the sale of future royalties.
Interest expense related to the sale of future royalties
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Contract with Customer, Basis of Pricing [Axis]
JAPAN
Japan [Member]
Purchase Commitments Under Drug Manufacturing Agreements
Purchase commitments under drug manufacturing agreements.
Minimum purchase commitments under drug manufacturing agreements
Depreciation, Depletion and Amortization, Total
Depreciation and amortization
Depreciation, Depletion and Amortization
Depreciation expense
R&D tax credit
Research and Development Tax Credit
Research and development tax credit.
R&D tax credit
R&D Tax Credit
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Grants vest percentage
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Noncash Investing and Financing Items [Abstract]
Supplemental disclosures of cash flow information:
Cybersecurity Risk Management Processes Integrated [Text Block]
Interest Expense, Nonoperating
Interest Expense, Nonoperating, Total
Interest (expense)
Interest (expense)
Leases
Lessee Operating And Finance Leases [Text Block]
Lessee operating and finance leases.
Equity [Text Block]
Stockholder's Equity
Title and Position [Axis]
Marketable Security, Realized Gain (Loss)
Realized (gain) loss from sale of marketable securities
Award Date [Axis]
Sale of Stock [Domain]
Utah [Member]
UTAH
Other Commitments [Line Items]
Other Commitments [Line Items]
Cashless exercise of pre-funded warrants, shares.
Cashless exercise of pre-funded warrants, shares
Entity Central Index Key
Entity Central Index Key
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Shares, Options Cancelled
Auditor Opinion [Text Block]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Common Stock, Shares, Issued, Total
Common stock, shares issued
Common Stock, Shares, Issued
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase (Decrease) in Prepaid Expense and Other Assets
Award Date [Domain]
Business Description and Basis of Presentation [Text Block]
Description of Business and Basis of Presentation
Income Statement [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of stock under employee stock purchase plan
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
(Loss) income before income taxes
(Loss) income before income taxes
Class of Warrant or Right [Table]
License, Supply and Distribution Agreement [TextBlock]
License, supply and distribution agreement.
License, Supply and Distribution Agreement
Carried forward indefinitely.
Carried Forward Indefinitely [Member]
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Additional shares of common stock to be registered, exclusively for grants of awards as material inducement
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Option to purchase additional shares of common stock
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Interest or penalties charges recognized
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
DRI Healthcare Trust [Member]
DRI Healthcare Trust.
DRI Healthcare Trust [Member]
Retirement Plan Name [Domain]
Lease, Cost [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Summary of Scheduled Maturity for Marketable Securities
Investments Classified by Contractual Maturity Date [Table Text Block]
Royalty Percentage on Annual Net Sales
Royalty percentage on annual net sales.
Royalty percentage on annual net sales
At market sales agreement.
At Market Sales Agreement Member
At-the-market Sales Agreement [Member]
Pre Commercial Planning Expenses
Pre-commercial planning expenses.
Pre-commercial planning
Cover [Abstract]
Subsequent Event [Line Items]
Maturing after two years through four years
Available For Sale Securities Debt Maturities After Two Through Four Years Fair Value
Available for sale securities debt maturities after two through four years fair value.
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, basic
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Change in valuation allowance
Lease description option to extend
Lessee, Operating Lease, Option to Extend
Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Annual Net Sales on Royalty Payments
Annual net sales on royalty payments.
Annual net sales on royalty payments
Operating Expenses [Abstract]
Operating Expenses:
U.K Employees Personal Pension Plan and U.S Employees 401 K Plan.
U.K Employees Personal Pension Plan And U.S Employees 401 K Plan [Member]
U.K. Employees Personal Pension Plan and U.S. Employees 401(K) Plan [Member]
Deferred revenue
Contract with Customer, Liability, Current
Document Annual Report
StockIssuanceCosts
Stock issuance Costs
Stock issuance costs
Consolidation Items [Domain]
Investments, Debt and Equity Securities [Abstract]
Upfront Payment Received
Upfront payment received.
Upfront payment received
Schedule of Cash and Cash Equivalents [Table Text Block]
Schedule of Cash and Cash Equivalents and Restricted Cash
June 2023 [Member]
June 2023.
Stock-based compensation expense
Share-based Payment Arrangement, Expense
Stock-based compensation
Issuance costs associated with royalty agreement.
Issuance costs associated with the royalty agreement
Accrued Research Expense Current
Accrued research expense current.
Accrued research expense
General and Administrative Expenses and Research and Development Expenses [Member]
General And Administrative Expenses And Research And Development Expenses [Member]
General and administrative expenses and research and development expenses.
Accumulated deficit
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Plan Name [Axis]
Segment Reporting [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Shares, Outstanding Beginning Balance
Shares, Outstanding Ending Balance
Annual 382 limitation.
Annual 382 Limitation [Member]
Annual 382 Limitation [Member]
Current assets:
Assets, Current [Abstract]
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for issuance upon exercise or settlement of stock options or other awards
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Non Rule 10b51 Arr Modified Flag
Non Rule 10b51 Arr Modified Flag.
Non-Rule 10b5-1 Arrangement Modified
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value Per Share, Forfeited
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Lessee, lease term
Lessee, Operating Lease, Term of Contract
Tax Period [Domain]
Operating Loss Carryforwards
NOL carryforwards
Property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net
Property and equipment, net
2029
Lessee, Operating Lease, Liability, to be Paid, Year Four
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities:
Common stock, par value
Common Stock, Par or Stated Value Per Share
Common stock, per share
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Percentage of share eligible to vest.
Percentage of share eligible to vest
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized holding gain on marketable securities
Unrealized holding gain from marketable securities
Statement of Cash Flows [Abstract]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Warrants to purchase shares of common stock
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Deferred Tax Assets, Other
Other
Equity Components
Equity Components [Axis]
Entity Address, Address Line One
Entity Address, Address Line One
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Accrued compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Shares, Granted
Number of Shares Outstanding, Awarded
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Computer Equipment [Member]
Property, Plant and Equipment [Line Items]
Deferred Tax Assets, Net of Valuation Allowance [Abstract]
Deferred tax assets:
Other receivables
Increase (Decrease) in Other Receivables
Subsequent Event Type [Axis]
Total other income
Nonoperating Income (Expense)
Interest and other income (expense), net
Schedule of Potential Dilutive Common Share Equivalents
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Indemnification Guarantee [Member]
Indemnification Agreement [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Additional performance stock units remaining
Number of Shares Outstanding, Outstanding Ending Balance.
Number of Shares Outstanding, Outstanding Beginning Balance
Shares outstanding
Entity Voluntary Filers
Fair value adjustment to derivative liability
Fair value adjustment to derivative liability.
Fair value adjustment to derivative liability
Amendment Flag
Amendment Flag
Operating Loss Carryforwards [Table]
Licensed Product, initial term
Licensed Product, initial term.
Lease liability - net of current portion
Operating Lease, Liability, Noncurrent
Long-term lease liabilities
Operating Lease, Liability, Noncurrent, Total
License, Supply and Distribution Agreement [Abstract]
License, supply and distribution agreement.
Domestic Tax Jurisdiction [Member]
U.S. Federal Income Tax [Member]
Corporate Debt Securities [Member]
Corporate Debt Securities [Member]
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock
Embedded Derivative, Fair Value of Embedded Derivative Liability
Fair value of derivative liability
Sale of Stock, Price Per Share
Offering price per share under subscription agreements
Realized gain (loss) on sale of securities.
Realized Gain (Loss) on Sale of Securities
Realized gain on sale of securities
Net loss
Net loss
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Research and development tax credit receivable
Increase Decrease In Research And Development Tax Credit Receivable
Increase decrease in research and development tax credit receivable.
Issuance of common stock from exercise of stock options, shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Shares, Options Exercised
Exercise of stock options, shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Shares, Exercisable
Research and Development Expense [Member]
Research and Development [Member]
Equity Component
Equity Component [Domain]
Statistical Measurement
Statistical Measurement [Domain]
Document Financial Statement Error Correction [Flag]
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
General & administrative
Royalty agreement amount funded
Royalty Agreement Amount Funded
Royalty agreement amount funded.
Other income (expenses), net
Other income (expenses), net
Other Nonoperating Income (Expense)
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Scheme termination period
Two thousand and seventeen equity incentive plan.
Two Thousand And Seventeen Equity Incentive Plan [Member]
2017 Equity Incentive Plan [Member]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Furniture and Fixtures [Member]
Cybersecurity Risk Management Processes Integrated [Flag]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Monthly lease payments
Operating Lease, Payments
Cash paid for amounts included in the measurement of operating lease liabilities
Proceeds from Stock Options Exercised
Total cash received as a result of employee stock option exercises
Retirement Benefits [Text Block]
Defined Contribution Plans
Payables and Accruals [Abstract]
Restricted cash
Restricted Cash, Current
Percentage of reduction in tax credit rates for small medium enterprise
Percentage of Reduction in Tax Credit Rates for Small Medium Enterprise
Percentage of reduction in tax credit rates for small medium enterprise.
Deferred Tax Liabilities, Other
Other
Other
UK Income from Royalty Financing
Effective Income Tax Rate Reconciliation UK Income from Royalty Financing
Effective income tax rate reconciliation UK income from royalty financing.
Issuance of pre-funded warrants for the purchase of common stock, net of issuance costs
Adjustments to Additional Paid in Capital, Warrant Issued
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of stock under employee stock purchase plan, shares
Consolidation Items [Axis]
Rent expense
Operating Lease, Expense
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total prepaid expenses and other current assets
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options Cancelled
Non-cash operating lease expense
Non Cash Operating Lease Expense
Non-cash operating lease expense.
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
2021 Equity Inducement Plan [Member]
Twenty Twenty One Equity Inducement Plan [Member]
2021 Equity Inducement Plan [Member]
US Employees 401K Plan.
U S Employees 401K Plan Member
U.S. Employees 401(K) Plan [Member]
Other Comprehensive Income (Loss), Net of Tax
Total other comprehensive (loss):
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding
Fair Value Measurement
Fair Value Measurement, Policy [Policy Text Block]
Number of patients reached in targeted enrollment
Number Of Patients Reached to Targeted Enrollment
Number of patients reached to targeted enrollment.
Rule 10b51 Arr Modified Flag
Rule 10b51 Arr Modified Flag.
Rule 10b5-1 Arrangement Modified
Payments to Acquire Debt Securities, Available-for-sale
Purchases of available for sale securities
Antidilutive Securities
Antidilutive Securities [Axis]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Total long-term liabilities
Liabilities, Noncurrent
January 2024 [Member]
January 2024.
Entity Interactive Data Current
Entity Interactive Data Current
Maturing in one year or less
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Marketable Securities [Table]
Marketable Securities [Table]
Kaken Receivable
Kaken receivable.
Kaken receivable (Note 12)
Remaining percentage of shares eligible to vest upon successful completion of NDA approval metric.
Remaining percentage of shares eligible to vest upon successful completion of NDA approval metric
Related Party Transaction [Domain]
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Beginning Balance
Total cash and cash equivalents and restricted cash
Statistical Measurement
Statistical Measurement [Axis]
Research Tax Credit Carryforward [Member]
R&D Credit Carryforward [Member]
Operating Lease, Cost
Operating lease costs
Financial Instruments, Financial Liabilities, Balance Sheet Groupings [Abstract]
Liability:
Related and Nonrelated Parties [Domain]
Lease, Cost
Total lease costs
Summary of Maturity of Undiscounted Payments and Future Minimum Payments Due Under Lease Liabilities and Present Value of Liabilities
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Option to receive one time cash payment
Option to receive one time cash payment.
Option to receive one time cash payment
Percentage of decrease in cash rebate that subcontracted research expenditures.
Percentage of decrease in cash rebate that subcontracted research expenditures
Percentage of decrease in cash rebate that subcontracted research expenditures
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of Activity In Connection With RSU
Stock awards, available for grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Shares, Grant date fair value
Weighted Average Grant Date Fair Value Per Share, Awarded
Unrecognized compensation costs, weighted average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation expense related to unvested awards expected to be recognized over a weighted-average period
Foreign Tax Jurisdiction [Member]
U.K. Income Tax [Member]
Foreign Tax Jurisdiction [Member]
Loss Contingency, Nature
Loss Contingency, Nature [Domain]
Machinery and Equipment [Member]
Deferred Tax Assets, Net
Net deferred tax asset
Research and Development Expense, Policy [Policy Text Block]
Research and Development
Research Expenses
Research expenses.
Research
Income Statement Location
Statement of Income Location, Balance [Axis]
Total assets
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected life of the options
Contract with Customer, Basis of Pricing [Domain]
Tax Period [Axis]
Purchase and Sales Agreement [Table]
Purchase and sales agreement.
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Interest Receivable and Other Assets
Interest and other receivables
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Accumulated Other Comprehensive Loss [Member]
AOCI Attributable to Parent [Member]
Deferred Royalty Obligation
Deferred royalty obligation.
Deferred royalty obligation
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other
Auditor Location
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Number of Shares Outstanding, RSUs Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Shares Outstanding, Forfeited
Number of shares forfeited
January 2023 [Member]
January 2023.
Not subject to annual 382 limitation.
Not Subject To Annual 382 Limitation [Member]
Schedule of Segment Reporting Information, by Segment [Table]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Stock-Based Compensation
Share-based Payment Arrangement [Text Block]
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Potential regulatory and sales milestone payment
Potential regulatory and sales milestone payment.
Potential regulatory and sales milestone payments
Fair Value Disclosures [Abstract]
Entity Public Float
Maturing after one year through two years
Available For Sale Securities Debt Maturities After One Through Two Years Fair Value
Available for sale securities debt maturities after one through two years fair value.
Issuance of common stock, net of issuance costs
Issuance of common stock, net of issuance costs
Stock Issued During Period, Value, New Issues
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax assets, net of valuation allowance
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Operating loss carry forwards expiration period.
Operating Loss Carry Forwards Expiration Period
Operating loss carry forwards expiration period
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Current liabilities:
Liabilities, Current [Abstract]
Number of non-executives eligible for share grant.
Number of non-executives eligible for share grant
Document Type
Document Type
Obligations of U.S. Government and Its Agencies [Member]
U.S. Government Agency Securities [Member]
US Government Agencies Debt Securities [Member]
Title of 12(b) Security
Title of 12(b) Security
Net operating loss carryforwards to offset future taxable income
Net operating loss carryforwards to offset future taxable income.
Net Operating Loss Carryforwards To Offset Future Taxable Income
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value
Annual Limitation [Member]
Annual Limitation [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Purchase Date
Percentage of discount for option to purchase common stock
Lessee, Operating Lease, Liability, to be Paid, Year Five
2030
Lease, Cost [Table Text Block]
Summary of Lease Costs
Finance lease costs.
Finance Lease Costs
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Document Fiscal Period Focus
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of stock options exercised
Research and Development Expense, Total
Research and development
Research and Development Expense
Research & development
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Shares, Options Granted
Massachusetts [Member]
MASSACHUSETTS
Earliest Tax Year [Member]
Maximum aggregate public offering price of securities to be issued under shelf registration statement.
Maximum Aggregate Public Offering Price Of Securities To Be Issued Under Shelf Registration Statement
Maximum aggregate public offering price of securities to be issued under shelf registration statement
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross
Total property and equipment at cost
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Subsequent Event Type [Domain]
Lessee, Leases [Policy Text Block]
Leases
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Fair Value of Share-based Awards Measured with Weighted-Average Assumptions
Operating Segments [Member]
SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis]
Percentage of Estimated Market Yield Used For Valuation of Derivative Liability
Percentage of estimated market yield used for valuation of derivative liability.
Percentage of estimated market yield used for valuation of derivative liability
Share based compensation arrangement by share based payment award recurring grants vesting period.
Share Based Compensation Arrangement By Share Based Payment Award Recurring Grants Vesting Period
Recurring grants vesting period
Employee stock purchase plan.
Employee Stock Purchase Plan [Member]
2017 Employee Stock Purchase Plan (ESPP) [Member]
Exercise price per share of each pre-funded warrant
Class of Warrant or Right, Exercise Price of Warrants or Rights
Financial Instruments
Financial Instruments [Domain]
United Kingdom [Member]
UNITED KINGDOM
Research And Development Tax Credit Receivable Policy Policy Text Block
Research and Development Tax Credit Receivable
Research and development tax credit receivable.
Percentage of reduction in payable tax credit for eligible research and development expenditures for small medium enterrpises.
Percentage of reduction in payable tax credit for eligible research and development expenditures for small medium enterrpises
Percentage of reduction in payable tax credit for eligible research and development expenditures for small medium enterrpises
Class of Warrant or Right [Line Items]
Sale of Stock [Axis]
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities:
Amounts associated with indemnifications
Amount Associated With Indemnification
Amount associated with indemnification.
Stock issued during period shares, restricted and performance stock units.
Stock issued during period shares, restricted and performance stock units
Release of restricted and performance stock units, shares
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Partnership revenue
Retirement Plan Name [Axis]
Income Tax Disclosure [Text Block]
Income Taxes
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation between Effective Tax Rates and Statutory Rates
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Defined Contribution Plan Disclosure [Line Items]
Other Commitments [Table]
Other Commitments [Table]
Other Accrued Liabilities, Current
Other accrued expenses
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Entity Address, Address Line Two
Entity Address, Address Line Two
Share-Based Payment Arrangement, Performance Shares, Outstanding Activity [Table Text Block]
Summary of Activity In Connection With PSU
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Property and equipment included in accounts payable and accrued expenses:
Noncash or Part Noncash Acquisition, Fixed Assets Acquired
Document Period End Date
Document Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Miscellaneous
Miscellaneous
Miscellaneous
Miscellaneous
Tax credit carry forward credits to expire unutilized.
Tax Credit Carry Forward Credits to Expire Unutilized
Credit to expire unutilized
ICFR Auditor Attestation Flag
Effective Income Tax Rate Reconciliation, Percent
Total
Stockholders' Equity Note [Abstract]
Long-term liabilities:
Liabilities, Noncurrent [Abstract]
Release of restricted stock units, shares
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Number of anti-dilutive potential common share equivalents outstanding
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
License, Supply and Distribution Agreement [Table]
License, supply and distribution agreement.
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Net proceeds from offering, after deducting estimated expenses
Sale of Stock, Consideration Received on Transaction
Transaction amount
Total accrued expenses
Accrued expenses
Accrued Liabilities, Current
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Segment reporting, CODM, profit (loss) measure, how used, description
Income Tax Expense (Benefit), Total
Income tax expense (benefit)
Income tax (benefit) expense
Provision for (benefit from) for income taxes
Trading Symbol
Trading Symbol
Total stockholders’ equity
Balance
Balance
Equity, Attributable to Parent
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released In Period
Share based compensation arrangement by share based payment award equity instruments other than options released in period.
Number of Shares Outstanding, Released
Deferred Tax Assets, Gross
Subtotal
Contingent liabilities
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual, Ending Balance
Loss Contingency Accrual
Long-Lived Tangible Asset [Axis]
Class of Warrant or Right, Outstanding
Pre-funded warrants outstanding
Share-Based Payment Arrangement [Policy Text Block]
Stock Based Compensation
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Sale of Stock, Number of Shares Issued in Transaction
Aggregate number of shares to issue and sell under subscription agreements
Variable Lease, Cost
Variable lease costs
Contractual obligations remaining clinical commitment including cancellation provisions.
Contractual Obligations Remaining Clinical Commitment Including Cancellation Provisions
Contractual obligations remaining clinical commitment including cancellation provisions
Property, Plant and Equipment [Table]
Cybersecurity Risk Management, Strategy, and Governance [Table]
Unrecognized compensation costs
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Nonrefundable upfront payment
Nonrefundable upfront payment.
Non-refundable upfront payment
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Schedule of Stock-Based Compensation Expense
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Defined Contribution Plan, Employer Discretionary Contribution Amount
Total employer contributions
Underwriters [Member]
Underwriters.
Underwriters [Member]
Geographical
Geographical [Axis]
Effective income tax rate reconciliation permanent adjustment.
Effective Income Tax Rate Reconciliation Permanent Adjustment
162(m) permanent adjustment
Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense related to unvested awards
Leases [Abstract]
Equipment [Member]
Laboratory Equipment [Member]
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Research and development tax credit receivable
Research And Development Tax Credits Receivable
Research and development tax credits receivable.
Purchase and Sale Agreement [Abstract]
Purchase and sale agreement.
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Contract balances
Security Exchange Name
Security Exchange Name
Summary of Fair Value of Company's Investments By Type
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Operating Loss Carryforwards [Line Items]
Total operating expenses
Operating Expenses
Total operating expenses
Long-Lived Tangible Asset [Domain]
Loss Contingency Nature
Loss Contingency Nature [Axis]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation
Fair Value Disclosures [Text Block]
Fair Value Measurements
2028
Lessee, Operating Lease, Liability, to be Paid, Year Three
Cash Cash Equivalents And Marketable Securities
Cash, cash equivalents and marketable securities
Cash cash equivalents and marketable securities.
Grant date fair value of performance share units
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value of stock options granted
Embedded Derivative Liability Policy
Embedded derivative liability policy.
Embedded Derivative Liability
Subsequent Event [Member]
Subsequent Event [Member]
Maximum [Member]
Maximum [Member]
Total liabilities and stockholders’ equity
Liabilities and Equity
Right of use assets
Operating Lease, Right-of-Use Asset
Prepaid Expense, Current, Total
Prepaid Expense, Current
Prepaid preclinical and clinical activities
Prepaid clinical activities
Retirement Benefits [Abstract]
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, diluted
Leasehold Improvements [Member]
Net operating loss carryforwards unutilized.
Net Operating Loss Carryforwards Unutilized
Net operating loss unutilized
Fair Value Hierarchy and NAV [Domain]
Total current assets
Assets, Current
Net Cash Provided by (Used in) Investing Activities
Net cash provided by investing activities
Issuance of common stock, net of issuance costs, shares
Stock Issued During Period, Shares, New Issues
Common stock, shares issued
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Unrecognized Tax Benefits
Provision for unrecognized tax benefits
Uncertain tax positions
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Nondeductible expenses - UK R&D credit
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Valuation allowance
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock options granted, vesting period
Entity Filer Category
Entity Filer Category
Property, Plant and Equipment [Abstract]
Other income:
Nonoperating Income (Expense) [Abstract]
Cash and cash equivalents and marketable securities fair value disclosure.
Cash And Cash Equivalents And Marketable Securities Fair Value Disclosure
Cash equivalents and marketable securities
Current Fiscal Year End Date
Current Fiscal Year End Date
License, Supply and Distribution Agreement [Line Items]
License, supply and distribution agreement.
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Expense From Change In Fair Value Of Derivative Liability
Expense from change in fair value of derivative liability.
Expense from change in fair value of derivative liability
Other income (expense) from change in fair value of derivative liability
Other income (expense) from change in fair value of derivative liability
Stock issued during period value, restricted and performance stock units.
Stock issued during period value, restricted and performance stock units
Release of restricted and performance stock units
Related Party Transaction [Axis]
Non-Executives.
Non-Executives [Member}
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding Beginning Balance
Aggregate Intrinsic Value, Outstanding Ending Balance
Aggregate Intrinsic Value, Outstanding Ending Balance
Related and Nonrelated Parties [Axis]
Clinical Development
Clinical development
Clinical development.
Entity Registrant Name
Entity Registrant Name
The entire disclosure for prepaid expense and other current assets.
Prepaid Expense And Other Assets Current Text Block
Prepaid Expenses and Other Current Assets
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Describes the periods of time over which an entity anticipates to receive utility from its property, plant and equipment (that is, the periods of time over which an entity allocates the initial cost of its property, plant and equipment).
Property, Plant and Equipment, Estimated Useful Life
Estimated useful life of property and equipment
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic
Derivative Liability, Notional Amount
Embedded derivative liability net carrying amount
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Common stock, shares authorized
Common Stock, Shares Authorized
Property, Plant and Equipment, Useful Life
Estimated useful life of property and equipment
Issuance of common stock, net of offering expenses
Proceeds from Issuance of Common Stock
Cash proceeds from issuance of common stock
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Vested and expected to vest
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Annual Net Sales Below Five Hundred Million [Member]
Annual Net Sales Below Five Hundred Million [Member]
Annual Net Sales Below 500.0 Million [Member]
Annual Net Sales Above Five Hundred Million [Member]
Annual net sales above five hundred million.
Annual Net Sales Above 500.0 Million [Member]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options Granted
Purchase and Sale Agreement [Line Items]
Purchase and sale agreement.
Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax, Total
Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax
Realized gain (loss) on sale of securities
Reclassification adjustment for realized (gain) loss on available for sale securities included in net loss
Reclassification adjustment for realized gain on marketable securities included in net loss
Reclassification adjustment for realized gain on marketable securities included in net loss
Financial Instrument
Financial Instrument [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Life, Outstanding
Regulatory And QA Expenses
Regulatory and QA expenses.
Regulatory & QA
Net Loss per Share
Earnings Per Share, Policy [Policy Text Block]
General and Administrative Expense [Member]
General and Administrative [Member]
Revenue [Policy Text Block]
Revenue Recognition
Share-based Payment Arrangement [Abstract]
Royalty payment obligations expiration period
Royalty Payment Obligations Expiration Period
Royalty payment obligations expiration period.
Stock Options and Awards [Member]
Employee Stock Options And Awards [Member]
Employee stock options and awards.
Issuance of pre-funded warrants
Proceeds from Issuance of Warrants
Non-cash interest expense and amortization of issuance costs
Non-cash interest expense and amortization of issuance costs.
Cybersecurity Risk Role of Management [Text Block]
Marketable securities
Debt Securities, Available-for-sale
Fair Value
Total investments
Accounting Policies [Abstract]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Option Activity
Income Tax Disclosure [Abstract]
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Common stock authorized offering amount under agreement to sell.
Common Stock Authorized Offering Amount Under Agreement To Sell
Aggregate offering price of common stock authorized
Embedded Derivative, Fair Value of Embedded Derivative, Net
Embedded Derivative, Fair Value of Embedded Derivative, Net, Total
Fair value of embedded derivative
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Effect of exchange rate changes on cash and cash equivalents
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Released Weighted Average Grant Date Fair Value
Share based compensation arrangement by share based payment award equity instruments other than options released weighted average grant date fair value.
Weighted Average Grant Date Fair Value Per Share, Released
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Statement [Table]
Statement [Table]
Segment Reporting
Segment Reporting, Policy [Policy Text Block]
Property, Plant and Equipment [Table Text Block]
Components of Property and Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Life, Vested and expected to vest
Subsequent Event [Table]
Number of executives eligible for share grant.
Number of executives eligible for share grant
Deferred Royalty Obligation Policy
Deferred royalty obligation policy.
Deferred Royalty Obligation
Entity File Number
Entity File Number
Segment Information
Segment Reporting Disclosure [Text Block]
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net increase (decrease) in cash and cash equivalents
Subject to 383 limitation.
Subject to 383 Limitation [Member]
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock compensation
Statement of Financial Position [Abstract]
Tax Credit Carryforward [Axis]
Operating Income (Loss)
(Loss) income from operations
Operating loss
(Loss) income from operations
Number of equity based compensation plans.
Number Of Equity Based Compensation Plans
Number of equity-based compensation plans
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility of the underlying stock
Entity Shell Company
Entity Shell Company
Accrued Professional Fees, Current
Accrued professional fees
Entity Tax Identification Number
Entity Tax Identification Number
Assets
Assets [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Life, Exercisable
Debt Securities, Available-for-Sale, Realized Gain (Loss), Total
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Realized gains (losses) on available-for-sale securities
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment
Subsequent Events [Abstract]
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Geographical
Geographical [Domain]
Document Fiscal Year Focus
Document Fiscal Year Focus
Other G&A
Other General and Administrative Expense
Securities Purchase Agreement [Member]
Securities purchase agreement.
Securities Purchase Agreement [Member]
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash and cash equivalents and restricted cash at beginning of year
Cash and cash equivalents and restricted cash at end of year
Tax Credit Carryforward, Amount
Tax credit carry forward amount
City Area Code
City Area Code
Total current liabilities
Liabilities, Current
Payments to Develop Software
Capitalized website development costs
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income tax benefit at U.S. federal statutory rate
Annual Net Sales Above Seven Hundred and Fifty Million [Member]
Annual net sales above seven hundred and fifty million.
Annual Net Sales Above 750.0 Million [Member]
KalVista Pharmaceuticals Limited [Member]
KalVista Pharmaceuticals Limited [Member]
KalVista Pharmaceuticals Limited [Member]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Schedule of estimated useful life of property plant and equipment.
Schedule Of Estimated Useful Life Of Property Plant And Equipment [Table Text Block]
Estimated Useful Life of Property and Equipment
Income Tax Jurisdiction [Axis]
Income Tax, Policy [Policy Text Block]
Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Components of the Company's Loss Before Income Taxes
Commitments and Contingencies Disclosure [Abstract]
Balance, shares
Balance, shares
Shares, Issued
Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Tax Effect of Significant Temporary Differences Representing Deferred Tax Assets and Liabilities
Lease liability - current portion
Operating Lease, Liability, Current
Current lease liabilities
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation (loss) gain
Foreign currency translation loss
Income Tax Jurisdiction [Domain]
Accumulated Deficit [Member]
Retained Earnings [Member]
Defined Contribution Plan [Table]
Acquisition of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Summary of Other Income and Expenses
Schedule of Other Nonoperating Income (Expense) [Table Text Block]
Performance based restricted stock unit [Member]
Performance Based Restricted Stock Unit [Member]
Performance Stock Units [Member]
Document Transition Report
Document Transition Report
Kaken Agreement [Member]
Kaken Agreement.
2027
Lessee, Operating Lease, Liability, to be Paid, Year Two
SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Derivative Liability, Statement of Financial Position [Extensible Enumeration]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign rate differential
Issuance of common stock from equity incentive plans
Proceeds from Stock Plans
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options Exercised
Auditor Firm ID
Minimum [Member]
Minimum [Member]
Proceeds from the royalty agreement
Proceeds from the royalty agreement.
Purchase and Sale Agreement
Purchase and Sale Agreement
Purchase and sale agreement.
Common Stock [Member]
Common Stock [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value Per Share, Outstanding Beginning Balance
Weighted Average Grant Date Fair Value Per Share, Outstanding Ending Balance
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Entity Well-known Seasoned Issuer
Debt Securities, Available-for-sale, Current, Total
Marketable securities
Debt Securities, Available-for-sale, Current
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive income (loss):
Other comprehensive (loss) income:
Income Statement Location
Statement of Income Location, Balance [Domain]
2026
Lessee, Operating Lease, Liability, to be Paid, Year One
Other Assets, Noncurrent, Total
Other assets
Other Assets, Noncurrent
Value Added Tax Receivable, Current
VAT receivable
Other Prepaid Expense, Current
Other prepaid expenses
Nonrefundable upfront payment received
Nonrefundable upfront payment received.
Realized Gain (Loss), Foreign Currency Transaction, before Tax
Foreign currency exchange loss (gain)
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
GILTI
Effective Income Tax Rate Reconciliation, GILTI, Percent
Contractual Obligation Remaining Commitment Including Cancellation Provisions
Contractual obligation remaining commitment including cancellation provisions.
Contractual obligations remaining clinical commitment including cancellation provisions
Title and Position [Domain]
Underwriting discounts, commissions, and other offering expenses
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Royalty payable upon completion of first commercial sale of DME
Royalty Guarantees, Commitments, Amount
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Common stock, $0.001 par value, 100,000,000 authorized Shares issued and outstanding: 34,171,138 and 24,550,748 as of April 30, 2023 and 2022, respectively
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued
Common stock, $0.001 par value, 100,000,000 authorized Shares issued and outstanding: 49,762,048 and 42,521,975 as of April 30, 2025 and 2024, respectively
Interest income
Investment Income, Interest
Interest income (expense), net
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Derivative Liability, Fair Value of Collateral
Fair value of the derivative liability
Other Nonoperating Income (Expense) [Abstract]
Subject to 382 limitation.
Subject To 382 Limitation [Member]
Subject To 382 Limitation [Member]
Deferred Tax Assets Capitalization
Deferred tax assets capitalization.
174 capitalization
Operating Lease, Liability
Total lease liabilities
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss ("NOL") carryforwards
Commitments and Contingencies
Commitments and contingencies (Note 9)
Number of legacy plans.
Number Of Legacy Plans
Number of legacy plans
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares outstanding, diluted
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Summary of Selected Financial Information with Respect to Single Operating Segment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Shares, Vested and expected to vest
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
Purchase And Sales Agreement [Abstract]
Purchase and sales agreement.
Cybersecurity Risk Management Third Party Engaged [Flag]
Pre-funded Warrants [Member]
Pre-funded Warrants Member
Pre-funded warrants.
Website development costs included in accounts payable.
Website development costs included in accounts payable
Website development costs included in accounts payable
Entity Small Business
Entity Small Business
Schedule of cash paid for amounts included in measurement of lease liabilities.
Schedule of Cash Paid for Amounts Included in Measurement of Lease Liabilities [Table Text Block]
Summary of Cash Paid for Amounts Included in Measurement of Lease Liabilities
Segment Reporting Information [Line Items]
Deferred tax liabilities operating lease right-of-use assets.
Deferred tax liabilities operating lease right-of-use assets
Operating lease - Right-of-use assets
Operating lease - Right-of-use assets
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Royalty Financing [Member]
Royalty financing.
Royalty Financing [Member]
Revenues, Total
Revenues
Revenue recognized
Sales-based milestone payment
Additional Cash Payment To Be Received
Additional cash payment to be received.
Additional cash payment to be received
Foreign Currency Transaction Gain (Loss), before Tax, Total
Gain (Loss), Foreign Currency Transaction, before Tax
Foreign currency exchange gain (loss)
Derivative Liability
Derivative Liability, Total
Derivative liability
Other Income (Expenses), Net
Other Nonoperating Income and Expense [Text Block]
Issuance of common stock from equity incentive plans
Stock Issued During Period, Value, Employee Benefit Plan
Direct Offering [Member]
Registered Direct Offering [Member]
Registered direct offering.
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding Beginning Balance
Weighted Average Exercise Price, Outstanding Ending Balance
Amortization of Debt Discount (Premium)
Amortization of premium on available for sale securities
State and Local Jurisdiction [Member]
State Income Tax [Member]
Right of use assets obtained in exchange for operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Less: valuation allowance
Amendment and Restated 2021 Equity Inducement Plan [Member]
Amendment and Restated 2021 Equity Inducement Plan [Member]
Amendment and Restated 2021 Equity Inducement Plan.
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term (years)
Percentage of Discount Rate Used for Valuation of Derivative Liability
Percentage of discount rate used for valuation of derivative liability.
Percentage of discount rate used for valuation of derivative liability
Subsequent Events [Text Block]
Subsequent Events
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Accounts payable
Accounts Payable, Current, Total
Accounts Payable, Current
Purchase and Sale Agreement [Member]
Purchase and sale agreement.
Increase (Decrease) in Accrued Liabilities, Total
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Short-Term Lease, Cost
Short-term lease costs